Balanced Chromosomal Translocations of Parents in Relation to Spontaneous Abortions

نویسندگان: ثبت نشده
چکیده مقاله:

The most significant complication of pregnancy is recurrent miscarriage. Numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects. Cytogenetic evaluation of couples with recurrent pregnancy losses is performed on the basis of G-banding technique only after other possible etiologic factors have been excluded. The purpose of this study was to determine the frequency of balanced translocation in 153 couples who were introduced to the medical genetic laboratory by gynecologists. The prevalence of balanced chromosomal translocation was 9.8% among which 3.3% appeared with Robertsonian translocation and the remaining (6.5%) was evident with different type of balanced chromosomal rearrangement. The yield of positive results for balanced chromosomal translocation carrier was lower than that expected. With regard to the low incidence of balanced translocation in normal population and high cost and time-consumption of chromosomal analysis cytogenetic investigation should be suggested only in couples with recurrent spontaneous abortions when clinical data fail to clarify the cause

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

balanced chromosomal translocations of parents in relation to spontaneous abortions

the most significant complication of pregnancy is recurrent miscarriage. numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects. cytogenetic evaluation of couples with recurrent pregnancy losses is performed on the basis of g-banding technique only after other possible et...

متن کامل

Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report

One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16 6) (p12 q26) and 46, X...

متن کامل

balanced chromosomal rearrangement in recurrent spontaneous abortions: a case report

one of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. we report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. chromosomal studies were performed on the basis of g-banding technique at high resolution and revealed 46, xx, t (16 6) (p12 q26) and 46, x...

متن کامل

Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report

One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46,...

متن کامل

Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran

Background Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materia...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 16  شماره 3

صفحات  -

تاریخ انتشار 2005-09-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023